CLINICAL AND BIOCHEMICAL STUDIES OF A PATIENT WITH A HILUS CELL TUMOUR

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Abstract
SUMMARY: A 27-year-old patient with a hilus cell tumour of the ovary giving rise to secondary amenorrhea and marked virilization was studied clinically and endocrinologically, and the tumour was examined by light and electron microscopy. Clinical, roentogenological and endocrinological studies showed that the ovarian tumour was the source of excessive androgen production. Urinary 17-oxosteroid excretion was always higher than 65 mg./day. The urinary production rates of testosterone, dehydroepiandrosterone and dehydroepiandrosterone sulphate were 1970 mg./day, 98·5 mg./day and 31·9 mg./day, respectively. Postoperatively, the androgenic manifestations gradually subsided, and the menstrual cycle returned to normal.

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