Synthesis of analogues of γ-aminobutyric acid. Part 11. Unsaturated and saturated tetronic acid [furan-2,4(3H,5H)-dione] derivatives
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 2983-2985
- https://doi.org/10.1039/p19830002983
Abstract
5-(2-Aminoethylidene)-4-hydroxyfuran-2(5H)-one (3) and the corresponding reduced 5-(2-aminoethyl) derivative (4) have been synthesised as conformationally restricted analogues of the neurotransmitter GABA. The use of the t-butyl protected reagents bis(t-butoxycarbonyl) amine and 5-ethylidene-4-t-butoxyfuran-2(5H)-one (7b) allowed generation of the required amino compounds under mild acidic deprotection conditions in the final step.This publication has 5 references indexed in Scilit:
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