Conformational modification of the PRP-hexapeptide by a direct covalent attachment of aromatic side chain groups

12 January 2009

journal article
research article
Published by Wiley in International Journal of Peptide and Protein Research

Vol. 32 (2) , 98-103
https://doi.org/10.1111/j.1399-3011.1988.tb00669.x

Abstract

PRP-hexapeptide possessing the azo-bridge between Tyr1 and Phe5 residues, called azo-PRP-hexapeptide was synthesized and tested for immunoregulatory activity. High biological activity of the synthesized azo-PRP-hexapeptide suggests that the biologically active conformation of PRP-hexapeptide must be such that both aromatic rings (Tyr and Phe) are apparently close to each other.

Keywords

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