Reduction of Estradiol-Binding Capacity of Neural Target Tissues in Light-Sterilized Rats

Publisher Website
Google Scholar
Abstract
Estradiol-binding capacity of the hypo-thalamus and parietal cortex, measured with tritiated estradiol, has been found to be significantly reduced in rats made anovulatory by exposure to continuous illumination when compared to controls of approximately equal weight maintained in a light-controlled (14 h light and 10 h dark) room. This finding suggests that constant light interferes with the normal replacement of estradiol-binding proteins in the brain. The decrease of the hypothalamic estrogen-receptors might account for the loss of the positive neurohormonal estrogen feedback inducing ovulatory LH release in the rat.

This publication has 0 references indexed in Scilit: