TIME-VARYING EFFECTS IN MICE AND RATS OF SEVERAL SYNTHETIC ACTH PREPARATIONS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (2) , 211-226
Abstract
Circadian stage-dependent effects characterize synthetic ACTH 1-17 preparation (HOE 433 = Synchrodyn 1-17), tested in mice and rats, with reference notably to corticosterone and aldosterone production in vitro and to the behavior of rhythms in these 2 corticoids as an aspect of the adrenal cortical pacemaker of the circadian system. The possibility to advance or delay the rhythm of serum corticosterone by ACTH 1-17 also is demonstrated, as is a differential behavior of the circadian rhythm of serum aldosterone. Differences in timing of circadian corticosterone and aldosterone responses also are described and await further scrutiny for ultradian and infradian (notably circannual) modulation.