Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut
- 1 April 1992
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 1 (1) , 50-55
- https://doi.org/10.1038/ng0492-50
Abstract
Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein. The deduced primary amino acid sequence of CDP reveals remarkable homology to Drosophila cut with respect to the presence of a unique homeodomain and "cut repeats". As cut participates in determination of cell fate in several tissues in Drosophila, the similarity predicts a broad role for CDP in mammalian development.Keywords
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