The novel anticonvulsant MK-801 interacts with central phencyclidine recognition sites in rat brain

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• Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists
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• The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate
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• Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties
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