Prevention of Experimental Arteritis in Dogs by Vitamin E.

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Abstract
Twenty-two of 25 dogs fed a kennel diet of selected table scraps to which was added each day for 8 wks. or longer 3.0 ml. of cod liver oil/kg. of body wt. developed typical arterial lesions when they died in uremia 7-35 days after the exptl. production of renal insufficiency. When vit. E (mixed natural tocopherols, 2.5 to 4.0 mg./kg./day by mouth) was administered along with the diet, none of 4 dogs subjected to the same exptl. procedures developed any arterial lesions. Vit. E was equally effective in preventing or retarding the arterial lesions when its admn. by mouth was started 0, 1, and 2 days after renal insufficiency was induced.

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