Comparative effect of viral and bacterial neuraminidase on the complement sensitivity of lymphoid cells.

  • 1 January 1972
    • journal article
    • Vol. 10  (1) , 139-50
Abstract
C3H/HeJ mouse lymphoid cells were exposed to Vibrio cholerae neuraminidase (VCN), Clostridium perfringens neuraminidase (CPN), and influenza virus neuraminidase (IVN). Exposure of mouse lymphoid cells to VCN or CPN in non-cytotoxic concentrations renders such cells susceptible to lysis by specific antibody and rabbit serum complement and by rabbit serum alone. Inactivation of complement eliminates the effect. Exposure of rabbit lymphoid cells to VCN or CPN renders them susceptible to lysis in the absence of antibody when autologous complement is activated within the fluid phase by cobra venom factor. IVN does not sensitize lymphoid cells to complement in these systems.