Susceptibility of 126 isolates ofEscherichia coil from the cerebrospinal fluid of neonates to five antibiotics

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Abstract
One hundred and twenty-six clinical isolates of Escherichia coh from the CSF of neonates, obtained in the Netherlands during 1976 to 1982, were tested for sensitivityto five antibiotics The usefulness of the generally recommended initial therapy, a combination of ampicillin and gentamicin, is supported in the majority of cases. On the basis of the n-vitro results, cefotaxime would have been effective as a therapy for all cases. Ampicillin and cefuroxime resistance occurred mostly in neonates who had received antibiotics prophylactically, neonates whose mothers had fever during labour or in neonates who had been nursed in incubators for more than one week.

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