THE RATE OF INCREASE IN HYPOPHYSEAL GONADO TROPIC CONTENT FOLLOWING OVARIECTOMY IN THE RAT, WITH OBSERVATIONS ON GLAND WEIGHTS1,2

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Abstract
The gonad-stimulating content of the hypophyses from normal 24-wk.-old [female][female] and [female][female] of the same age gonadectomized 5, 10, 20, 30, 60 and 120 days prior to autopsy was evaluated in terms of an arbitrary uterine unit. The potency per gland in the respective castrated groups was found to be 3.7, 7.0, 20.7, 31.2, 52.7 and 51.9 times greater than normal. Body wt. and length increased in proportion to the time elapsed between castration and autopsy. There was no consistent effect on pituitary and thyroid wts., and no significant atrophy of the adrenals was found. Hypertrophy of the thymus reached a maximum increase of 240% over normal by the 30th day after ovariectomy. Increase in kidney wt. was roughly proportional to body growth except in the 60 and 120-day castrates.

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