Polyphosphate Ester-Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction

1 July 1998

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 1998 (7) , 718-720
https://doi.org/10.1055/s-1998-1764

Abstract

Dihydropyrimidines 7 are prepared in high yield by a one-pot condensation of aldehydes, acetoacetates, and ureas using a polyphosphate ester-mediated cyclocondensation reaction. Yields are significantly higher than utilizing classical Biginelli reaction conditions.

Keywords

BIGINELLI REACTION
DIHYDROPYRIMIDINES
N-ACYLIMINIUM IONS
POLYPHOSPATE ESTER
CALCIUM CHANNEL MODULATORS

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