Id family of helix-loop-helix proteins in cancer
Top Cited Papers
- 20 July 2005
- journal article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (8) , 603-614
- https://doi.org/10.1038/nrc1673
Abstract
Over the past few decades, biologists have identified key molecular signatures associated with a wide range of human cancers. Recently, animal models have been particularly useful in establishing whether such signatures have functional relevance; the overexpression of pro-oncogenic or loss of anti-oncogenic factors have been evaluated for their effects on various tumour models. The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.Keywords
This publication has 125 references indexed in Scilit:
- Id4 is required for the correct timing of neural differentiationDevelopmental Biology, 2005
- Id4regulates neural progenitor proliferation and differentiation in vivoDevelopment, 2004
- Self-renewal and solid tumor stem cellsOncogene, 2004
- E Protein Silencing by the Leukemogenic AML1-ETO Fusion ProteinScience, 2004
- Id genes and proteins as promising targets in cancer therapyTrends in Molecular Medicine, 2004
- BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3Cell, 2003
- TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient miceJournal of Allergy and Clinical Immunology, 2003
- ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic valueOncogene, 2003
- Over Expression of ID-1 in Prostate CancerJournal of Urology, 2002
- A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex.Genes & Development, 1993