Effect of primycin on monovalent cation transport of erythrocyte membrane and lipid bilayer.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (4) , 408-413
- https://doi.org/10.7164/antibiotics.32.408
Abstract
The effects of primycin on the alkali-cation transport of human erythrocytes and on the electric conduction of bimolecular lipid membranes were investigated. In the concentration range of 3 .cntdot. 10-6 to 10-5 primycin increased the permeability of erythrocytes to alkali-cations according to the sequence Cs+ > Rb+ .apprx. K+ .mchgt. Na+, while the conductance of the negatively charged phosphatidylserine bimolecular lipid membrane increased by 2-3 orders of magnitude. The resistance-lowering effect of primycin strongly depended on the cationic species applied and a selectivity order Na+ > K+ > Rb+ > Cs+ was found. A possible mechanism of the primycin-membrane interaction is suggested on the basis of experimental data.This publication has 5 references indexed in Scilit:
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