Stable Tetravalent Phosphonium Enolate Zwitterions
- 1 May 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 129 (21) , 6722-6723
- https://doi.org/10.1021/ja071990s
Abstract
Three-component coupling reactions between trialkylphosphines, methyl propiolates, and aldehydes produced 1:1:1 dipolar adducts in moderate to excellent yields. The product phosphonium enolate zwitterions were isolated as crystalline solids. X-ray crystallographic analyses of these single crystals established unequivocally the dipolar structures of these tetravalent phosphonium enolate zwitterions. Because phosphonium enolates are the first key intermediates in the nucleophilic phosphine-mediated catalysis of α,β-unsaturated carbonyl compounds, this study provides crucial insight into the mechanisms of Morita−Baylis−Hillman-type reactions.Keywords
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