Regulation of urinary steroid excretion. 1. Effects of dehydroisoandrosterone and of anterior pituitary extract on the pattern of daily excretion in man

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Abstract
Admn. of dehydroisoandrosterone produced in several mental patients a marked rise in the excretion of 3([alpha])-hydroxy-17-ketosteroids. Increases of cortin and of estrogens were noted in a few cases. The anterior pituitary-lobe extract, Ambinon, produced a net fall in the excretion of the 3([alpha])-hydroxy-17-ketosteroids, usually accompanied by a rise in total estrogen excretion. Possible mechanisms for the changes described above are discussed.