Oral immunization with an anti–idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection
- 1 October 1996
- journal article
- Published by Springer Nature in Nature Medicine
- Vol. 2 (10) , 1116-1121
- https://doi.org/10.1038/nm1096-1116
Abstract
Chlamydia trachomatis is the leading cause worldwide of preventable infectious blindness (trachoma) and sexually transmitted disease, including nongonoccocal urethritis and pelvic inflammatory disease. To date, no effective vaccine against C. trachomatis infection has been identified. A monoclonal anti-idiotypic antibody (anti-Id) to the chlamydial exoglycolipid antigen (GLXA) was tested in a murine model of ocular chlamydial infection for its ability to induce systemic immunity, which reduces microbiologic and clinical disease. The anti-Id to GLXA, delivered either systemically in soluble form or orally after encapsulation in poly(lactide) microspheres, induced significant protective immunity against ocular challenge of mice with a human biovar of C. trachomatis. Protection was associated with induction of anti-GLXA antibody and anti-chlamydial neutralizing antibody.Keywords
This publication has 22 references indexed in Scilit:
- Molecular basis of antigen mimicry by an anti-idiotopeNature, 1995
- Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: serum neutralizing IgG antibodies do not protect against chlamydial genital tract infectionVaccine, 1995
- Controlled Intracranial Delivery of Antibodies in the RatPublished by American Chemical Society (ACS) ,1994
- Partial protection against genital reinfection by immunization of guinea-pigs with isolated outer-membrane proteins of the chlamydial agent of guinea-pig inclusion conjunctivitisJournal of General Microbiology, 1993
- A Genetic Approach to Idiotypic VaccinationJournal of Immunotherapy, 1993
- Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patchesJournal of Controlled Release, 1990
- T cell activation by anti-idiotypic antibody: mechanism of interaction with antigen-reactive T cellsEuropean Journal of Immunology, 1987
- Overview of Chlamydia trachomatis Infection and the Requirements for a VaccineClinical Infectious Diseases, 1985
- THE IgA RESPONSE: INDUCTIVE ASPECTS, REGULATORY CELLS, AND EFFECTOR FUNCTIONSAnnals of the New York Academy of Sciences, 1983
- Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine productionClinical Immunology and Immunopathology, 1981