MALIGNANT HISTIOCYTOSIS Histiocytic Medullary Reticulosis

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Abstract
Three cases of malignant histiocytosis occurring in children aged 2 mo., 10 mo. and 14 yr are described. In all children the diagnosis was based on anemia, granulocytopenia or thrombocytopenia, splenomegaly and marked erythrophagocytosis by bone marrow and lymph node atypical histiocytes. Two children, aged 10 mo. and 14 yr, underwent splenectomy after which combined chemotherapy with cyclophosphamide, vincristine and prednisone (COP) was started. In the older child a complete remission was achieved. The younger child died soon after onset of treatment. The youngest child was treated with bleomycin, adriamycin, cyclophosphamide, vincristine and prednisone (BACOP). He died of pneumonia and sepsis 2 mo. after treatment was started.

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