STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA XI: DIAMORPHINE (HEROIN) AND MORPHINE

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Abstract
The pre-operative effects, influence on the course of methohexitone anaesthesia and influence on postoperative complications of premedication with diamorphine 5 mg and 7.5 mg were compared with those following morphine 10 mg and 15 mg. The sedative action of diamorphine occurred earlier than that of morphine and its soporific effect was slightly more marked. Diamorphine was found to have a shorter duration of action and this may account for the higher incidence of excitatory phenomenon and more rapid recovery from anaesthesia associated with its use. Emetic sequelae following diamorphine 5 mg and morphine 10 mg did not differ significantly, but the increased incidence at the higher dose was less in the case of diamorphine.

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