The tricarboxylic acid pathway in Desulfovibrio

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Abstract
Strains of 2 Desulfovibrio spp. were examined for enzymes of the tricarboxylic acid cycle and related pathways. Pyruvate carboxylase (EC 6.4.1.1) is present, and .alpha.-ketoglutarate is formed via the tricarboxylic acids. Glutamate, but not succinyl-CoA, arises from .alpha.-ketoglutarate. A pathway exists from pyruvate by malic enzyme (EC 1.1.1.39) activity to malate, then fumarate and succinate, again with no evidence of succinyl-CoA formation. The enzymes concerned with metabolism of these dicarboxylic acids show greater activity in the strains that can grow by fumarate dismutation. Glutamate (or glutamine), .alpha.-ketoglutarate, and yeast extract repress the enzymes that metabolize the tricarboxylic acids. There appears to be no glyoxylate cycle in D. vulgaris or D. desulfuricans.

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