EFFECTS OF RADIATION TYPE AND DOSE AND ROLE OF GLUCOCORTICOIDS, GONADECTOMY, AND THYROIDECTOMY IN MAMMARY-TUMOR INDUCTION IN MAMMOTROPIN-SECRETING PITUITARY TUMOR-GRAFTED RATS
- 1 January 1978
- journal article
- research article
- Vol. 38 (6) , 1507-1513
Abstract
Three experiments on the induction of mammary neoplasms by total-body 11- to 100-rad neutron or 50- to 500-rad .gamma.-radiation of female Fischer or W/Fu rats are reported. Grafts of mammotropin-secreting pituitary tumor were used to elevate mammotropic hormone levels. The results confirm and extend previous reports that neutrons are more efficient in carcinoma induction than .gamma.-rays (the neutron relative biological effectiveness for 1st carcinomas was 3.68) and demonstrate that the potentiation of carcinoma induction by adrenalectomy is reversed by glucocorticoid replacement. Statistical analysis of the data by procedures that take into account time at risk as well as tumor frequency indicates that multiple mammary tumors do not occur independently (i.e., a 1st mammary neoplasm significantly increases the probability of development of another neoplasm). The statistical procedure used in this analysis is presented.This publication has 3 references indexed in Scilit:
- Morphological and quantitative studies of gland formation from inocula of monodispersed rat mammary cellsExperimental Cell Research, 1977
- EFFECTS OF GRAFTS OF SINGLE ANTERIOR-PITUITARY GLANDS ON INCIDENCE AND TYPE OF MAMMARY NEOPLASM IN NEUTRON-IRRADIATED OR GAMMA-IRRADIATED FISCHER FEMALE RATS1976
- RESULTS OF FRACTIONATION AND PROTRACTION OF TOTAL-BODY RADIATION ON RAT MAMMARY NEOPLASIA1966