6-Thioguanine: Antimitotic Effect on Human Lymphocytes in vitro Prevented by Adenine
Open Access
- 1 March 1971
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 25 (1) , 106-108
- https://doi.org/10.1038/bjc.1971.15
Abstract
The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase.Keywords
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