The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea‐pig heart
Open Access
- 1 January 1973
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 47 (1) , 85-96
- https://doi.org/10.1111/j.1476-5381.1973.tb08161.x
Abstract
Summary: Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea‐pig isolated heart. The antiarrhythmic effect of DPH and K on ouabain‐induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.Keywords
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