THE NATURE OF THE FOODSTUFFS OXIDIZED TO PROVIDE ENERGY IN MUSCULAR EXERCISE

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Abstract
Experiments are reported in which the excess metabolism of exercise and recovery has been studied in 3 dogs running on a horizontal treadmill during the development of phlorhizin diabetes. The experiments were performed following the administration of glucose. In 2 of the animals there was a close correspondence between the respiratory quotients in rest and in exercise. In the 3rd the respiratory quotient of the excess metabolism was lower, after phlorhizinization, than that of the resting metabolism, and approached the theoretical value for fat. The results indicate that in the phlorhizinized animal, even though a hyper-gly-cemia exist, there is a diminution in the oxidation of carbohydrate by the organism as a whole, the muscles sharing in this to at least an equal degree. Under these circumstances the fuel requirement in both rest and exercise is provided by the oxidation of fat to a greater extent than in the normal animal. Under the conditions of the experiments the ability to oxidize sugar was not entirely lost, although D to N ratios approximating 3.65:1 were obtained.

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