Effect of Adrenergic Blocking Agents on Tyramine-Induced Release of Catecholamines from the Cat Heart.

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Abstract
The release of catecholamines induced by tyramine in the Langendorff preparation of the cat heart was inhibited by phenoxybenzamine and GD-131 (a, [beta]-haloalkylamine without alpha-adrenergic blocking activity). The release was not inhibited by phentolamine or dihydroergotamine. Those agents which inhibited the release of catecholamines also inhibited the positive inotropic action of tyramine. The possibility is suggested that [beta]-haloalkylamines may interfere with the release of catecholamines in vivo as well as inhibiting the effects of catecholamines on effector cells.

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