Astrocyte Activation and Apoptosis: Their Roles in the Neuropathology of HIV Infection
- 1 January 2003
- journal article
- review article
- Published by Wiley in Brain Pathology
- Vol. 13 (1) , 84-94
- https://doi.org/10.1111/j.1750-3639.2003.tb00009.x
Abstract
Astrogliosis is a common neuropathological finding in the brains of HIV infected individuals; both activation and apoptosis of astrocytes are seen. This review aims to discuss the Fas pathway in the context of proliferation and apoptosis of astrocytes during HIV infection, and as a result of astrogliosis, the dysregulation of astrocyte-neuron networks. The presence of molecules reflecting astrocyte activation, which are derived from the sol-ubilization of receptor/ligand from the surface of proliferating astrocytes, in the cerebrospinal fluid may be used to evaluate the degree of brain cell activation during HAART therapy. A better understanding of the molecular pathway(s) leading to increase activation and apoptosis of astrocytes, in parallel with studies conducted to unravel the molecules involved in T-cell apoptosis during HIV infection, may lead to the development of new therapeutic strategies for controlling HIV replication and tissue damage.Keywords
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