Sterospecific syntheses of marcrobicyclic polyethers with carbon bridgeheads from chiral glycerol derivatives
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 20,p. 1356-1360
- https://doi.org/10.1039/c39840001356
Abstract
The [3.3.3]cryptand (3), prepared stereospecifically from 2,3-O-isopropylidene-D-glycerol D-(1) and 2,3-di-O-benzyl-L-glycerol L-(2), has been separated chromatographically at –5 °C into slowly interconverting in-in ii-(3) and out-out oo-(3) conformational diastereoisomers [ΔGii→oo ‡=ca. 24 kcal mol–1(1 kcal = 4.184 kj) in CD3COCD3 at +38 °C]; an X-ray structure analysis has shown (3) to from a crystalline 1 : 1 complex with Ba(SCN)2 in which the Ba2+ ion is encapsulated by oo-(3) and the two SCN– ion in an 11-co-ordinate manner.Keywords
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