PHOTOSENSITIVE CATARACTOGENS, CHLORPROMAZINE AND METHOXYPSORALEN, CAUSE DNA-REPAIR SYNTHESIS IN LENS EPITHELIAL-CELLS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 17  (7) , 687-691
Abstract
Photoactivation of methoxypsoralen or chlorpromazine caused diffuse nuclear labeling of Osborne-Mendel rats lens epithelial cells by thymidine. Chlorpromazine and light also induced thymidine incorporation into lymphocytes, whereas light or drug alone did not cause unscheduled DNA synthesis.

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