Antioxidant Effects of Angiotensin-Converting Enzyme (ACE) Inhibitors: Free Radical and Oxidant Scavenging are Sulfhydryl Dependent, but Lipid Peroxidation is Inhibited by Both Sulfhydryl- and Nonsulfhydryl-Containing ACE Inhibitors
- 1 March 1992
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 19 (3) , 330-340
- https://doi.org/10.1097/00005344-199203000-00005
Abstract
Summary: With an assay that generates free radicals (FR) through photooxidation of dianisidine sensitized by riboflavin, 4 × 10−5M captopril, epicaptopril (SQ 14,534, captopril's stereoisomer), zofenopril, and fentiapril [all sulfhydryl (-SH)-containing angiotensin-converting enzyme (ACE) inhibitors] were shown effective scavengers of nonsuperoxide free radicals whereas non-SH ACE inhibitors were not. Captopril was a more effective FR scavenger at pH 5.0 than at pH 7.5. Captopril (2 × 10−5M) also scavenged the other toxic oxygen species hydrogen peroxide and singlet oxygen and inhibited microsomal lipid peroxidation. Finally, captopril reduced the amount of superoxide anion-radical detected after neutrophils in whole blood were activated with zymosan, probably by inhibiting leukocyte superoxide production.Keywords
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