Effects of Cold Exposure or TRH on the Serum TSH Levels in the Iron-Deficient Rat
- 1 October 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 20 (10) , 616-619
- https://doi.org/10.1055/s-2007-1010899
Abstract
Normal and iron-deficient rats were exposed to cold at 4°C for 1 hr or 5 hrs and the serum TSH, T3 and T4 levels were compared with those in rats kept at room temperature (20°C). There was a rise in serum TSH, T3 and T4 levels in response to 1 hr and 5 hrs of cold exposure in normal, but not in iron-deficient rats. Although pituitary TSH contents were lower in iron-deficient rats, the increases in serum levels of TSH following administration of TRH were similar in both normal and iron-deficient rats. The results suggest that the inability to respond to cold in iron-deficient rats may be due to a reduction in the release of TRH from the hypothalamus.Keywords
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