CATECHOLAMINE AND ACID-BASE CHANGES DURING ANAESTHESIA AND THEIR INFLUENCE UPON THE ACTION OF PROPRANOLOL

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Abstract
During ether anaesthesia the plasma noradrenaline level is increased and the pH of the blood unaltered. In these circumstances the intravenous injection of 1 mg propranolol has no effect on the arterial pressure. When methoxyflurane and halothane are inhaled there is no change in circulating catecholamine concentrations and plasma pH is reduced because of the associated respiratory acidosis. During anaesthesia with these agents there is a significant fall in arterial pressure following the administration of propranolol. It is suggested that the prevailing acid-base state is a more important factor than plasma noradrenaline levels in determining the effect of propranolol during anaesthesia.

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