IMMUNOLOGIC ASPECTS OF CONGENITAL RUBELLA

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Abstract
A study of 16 infants with congenital rubella virus infection revealed that: (1) males tended to excrete virus longer than females; (2) termination of infection was often preceded by a transitional period of declining virus titers; (3) serum antibodies to rubella virus rose during this time; (4) prolonged elevation of serum IgM correlated with persistent infection; (5) a broad scale immunoparesis may be present during the infective period, involving both humoral and cellular factors as well as such diverse antigens as those from red blood cells, fungi, bacteria and viruses; and (6) this immunologic incompetence is not associated with immunoglobulin deficiency nor inability of the infant to produce antibodies against the rubella virus.

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