THE EFFECT OF SEVERE ZINC-DEFICIENCY ON THE MORPHOLOGY OF THE RAT RETINAL-PIGMENT EPITHELIUM
- 1 January 1982
- journal article
- research article
- Vol. 23 (4) , 425-434
Abstract
Male Sprague-Dawley weanling rats maintained on a controlled dietary Zn intake had an accumulation of osmiophilic inclusion bodies in the retinal pigment epithelium (RPE) of the Zn-deficient group. At 7 wk of Zn deficiency there were marked ultrastructural alterations of the RPE. In some instances, a deepening of the basal infoldings of the cells of the RPE was observed. There was also vesiculation and degeneration of the photoreceptor outer segments. No changes were observed in the pair-fed, weight-restricted and ad lib-fed controls. The possible functions of Zn in the retina are discussed.This publication has 4 references indexed in Scilit:
- Ileal Paneth cells and IgA system in rats with severe zinc deficiency: An immunohistochemical and morphological studyJournal of Molecular Histology, 1980
- Zinc Deficiency and Visual Impairment?American Journal of Ophthalmology, 1978
- Zinc deficiency: a cause of abnormal dark adaptation in cirrhotics1–4The American Journal of Clinical Nutrition, 1978
- A Zn++ Requirement for Synthesis of Deoxyribonucleic Acid by Rat LiverJournal of Biological Chemistry, 1964