The metabolism of dibenzylamine: identification of NN-dibenzylhydroxylamine as the major in vitro metabolic product from rabbit fortified hepatic homogenates
- 1 September 1975
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (9) , 659-665
- https://doi.org/10.1111/j.2042-7158.1975.tb09528.x
Abstract
A study of the in vitro metabolism of dibenzylamine with fortified rabbit liver 9000 g supernatant fractions has shown that N-oxidation is the major metabolic process. Of the total amount of dibenzylamine metabolized, 90% is converted to NN-dibenzylhydroxylamine. The primary amine, benzylamine, is formed to the extent of only 6% of total substrate metabolized. The identity of the major metabolite, NN-dibenzylhydroxylamine has been established by thin-layer chromatography, gas-liquid chromatography and combined gas-liquid chromatography-mass spectrometry.Keywords
This publication has 10 references indexed in Scilit:
- Metabolic incorporation of oxygen into primary and secondary aliphatic amines and the consequences in carbon-nitrogen bond cleavageJournal of Pharmacy and Pharmacology, 1975
- The Identification of Three New Metabolic Products of Phentermine after Liver Microsomal IncubationXenobiotica, 1974
- Synthesis of N-alkyl-N-hydroxyamphetamines and related nitronesTetrahedron, 1973
- THE IMPORTANCE OF THE ‘HYDROXYLAMINE METABOLIC ROUTE’ IN PHARMACOLOGY, TOXICOLOGY AND PHARMACOKINETICSPublished by Elsevier ,1973
- The metabolism of (+)- and (-)-amphetamine and (+)- and (-)-dimethylamphetamine in rabbits in vivoBiochemical Journal, 1972
- Microsomal N-Oxidation of Dapsone as a Cause of Methemoglobin Formation in Human Red Cells *The American Journal of Tropical Medicine and Hygiene, 1972
- Metabolic Oxidation of Aliphatic Basic Nitrogen Atoms and their α-Carbon AtomsXenobiotica, 1971
- The GLC Separation of Hydroxyl-Substituted Amines of Biological Importance Including the Catecholamines. Preparation of Derivatives for Electron Capture DetectionAnalytical Letters, 1968
- A new method for the separation of the catecholamines by gas-liquid chromatographyBiochimica et Biophysica Acta (BBA) - General Subjects, 1967
- Determination and identification of amphetamine in urineJournal of Pharmacy and Pharmacology, 1965