Biosynthesis of aspyrone and asperlactone, pentaketide metabolites of Aspergillus melleus. Incorporation studies with [1-13C, 18O2]acetate and 18O2 gas
- 1 January 1985
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 23,p. 1685-1687
- https://doi.org/10.1039/c39850001685
Abstract
Incorporation of [1-13C,18O2] acetate and 18O2 gas into aspyrone (1) and asperlactone (2) by cultures of Aspergillus melleus and observation of 18O isotope-induced shifts in the 13C n.m.r. spectra of the enriched metabolites establish the origins of all the oxygen atoms and suggest a biosynthetic pathway involving epoxide-mediated rearrangement and ring closure reactions.Keywords
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