PHARMACOKINETICS OF CEFOXITIN IN PATIENTS UNDERGOING HEMODIALYSIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 17  (8) , 366-370
Abstract
The pharmacokinetics of cefoxitin were studied after an i.v. administration of 15 mg/kg body weight in 17 patients with terminal renal impairment, 10 of which were undergoing 6 h hemodialysis sessions. The average pharmacokinetic parameters obtained from this kind of patient were determined. The amounts of the antibiotic in the central and peripheric compartments are established together with the amount of the antibiotic eliminated as a function of time. The pharmacokinetic parameters are significantly different from those established in the period between dialysis sessions, and thus, the elimination constant reaches a value of 0.28 h-1. The degree of plasma protein binding of cefoxitin is 41.46% during the hemodialysis sessions. A dosage regimen is programmed as a function of the pharmacokinetic parameters established for this kind of patient. It is recommended that an i.v. dose of 15 mg/kg body weight should be administered at the beginning and end of each dialysis session lasting 6 h when the periods between the sessions are 48 h.

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