Excretion of Levamisole in Milk from Cows Treated with Various Formulations

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Abstract
The rate of disappearance of [the anthelmintic] levamisole in milk from cows given levamisole hydrochloride drench, levamisole resinate in feed pellets, levamisole hydrochloride boluses or levamisole phosphate injectable was determined. Each formulation was given as a single treatment to each of 5 cows at a rate equivalent to 8 mg of levamisole hydrochloride/kg of body weight. Levamisole hydrochloride residues in milk averaged .50, .55, .58 and .32 ppm at 12 h after the administration of levamisole drench, feed, bolus and injectable formulations. Levamisole hydrochloride residues were below .01 ppm in milk at 48 h after drench treatment and at 60 h after treatment with the other 3 formulations. Toxicity symptoms were not observed in any cows following treatment.

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