Improved Methods for Production, Isolation, and Assay of Two New Chloroisoxazoline Amino Acid Antitumor Antimetabolites: U-42,126 and U-43,795
- 1 June 1975
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 7 (6) , 807-810
- https://doi.org/10.1128/aac.7.6.807
Abstract
Improved fermentation and isolation procedures for antitumor antimetabolites U-42,126 and U-43,795 increased drug yields 30-fold. The sensitivity limit of a newly developed assay is 0.03 μg of U-42,126 and 2.0 μg of U-43,795 per ml. The in vitro antimicrobial effect of both drugs was antagonized by histidine.Keywords
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