AN OBSERVATION ON THE EFFECT OF STRYCHNINE ON LOCAL CORTICAL POTENTIALS

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Abstract
Local application of strychnine to the cortical surface could increase the size and the promptness of onset pf the 2d component of the local cortical potential without significantly affecting the 1st component. When the action of strychnine was fully developed, the 2 components became fused into a single wave which could be dissociated again into 2 temporally separated waves by reducing the stimulus strength. The effect of strychnine is to accelerate the process of impulse initiation of individual neurons in the central nervous system, so as to increase the efficiency of summation and to increase the chance of synchronization.