Relaxant effects on iloprost in canine cerebral artery
- 1 May 1992
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 70 (5) , 712-716
- https://doi.org/10.1139/y92-092
Abstract
Iloprost caused relaxation of rings of canine cerebral arteries precontracted with prostaglandin F2α or the thromboxane A2 analogue U46619, but it was without effect on arteries precontracted with potassium chloride. Pretreatment with iloprost did not significantly affect the concentration–response curve to any agent. Contractile responses to oxyhemoglobin were completed relaxed by iloprost. In arteries from animals with moderate cerebrovascular spasm, the response to prostaglandin F2α was also reduced by iloprost. The observation that iloprost relaxes the response to oxyhemoglobin to prostaglandin F2α in spastic arteries may be of interest in the management of cerebral vasospasm.Key words: iloprost, eicosanoid, oxyhemoglobin, relaxation, vasospasm.Keywords
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