Effect of Magnesium Deficiency on Intestinal Calcium Transport in Rats

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Abstract
Summary Calcium transport across the duodenum and ileum was measured by an in vivo ligated loop technique in Mg depleted rats and rats pair fed a magnesium adequate diet. Intestinal Ca transport and tibial 47Ca uptake were consistently decreased in magnesium depletion. Analysis of Ca fluxes, carried out by in situ perfusion, showed a significant decrease in passive diffusion, with less consistent effects on the saturable transport component. Both bone and plasma showed markedly decreased Mg concentration. Tibia Ca levels were slightly but significantly increased and plasma levels were either normal or slightly, but significantly elevated. The basis for the decrease in Ca transport of Mg depleted rats observed in this investigation is not clear. The data suggest a general alteration in mucosal membrane transport rather than a specific effect on Ca transport per se.