Phialophora dermatitidis; Its morphology and biology

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Abstract
Isolates of Phialophora dermatitidis obtained from human infections of the skin and underlying organs were divided into 2 morphologic types on the basis of their colony appearance and microscopic properties. The virulence of these fungi was established for normal and predisposed mice, and their ability to invade different organs determined by isolation data and by histopathology. All strains studied were neurotropic. Using the broth dilution technique, Amphotericin B was found to be fungicidal at levels of 2·5 μg./ml. and 5·0 μg./ml. depending upon the length of exposure to the drug. The taxonomic status of the fungi is reviewed with the recommendation that the species be retained in the genus Phialophora.