RETARDATION OF BONE-GROWTH IN TRIAMCINOLONE-TREATED MICE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 121  (JUL) , 515-535
Abstract
Immature mice were treated for up to 8 wk with daily doses of triamcinolone diacetate. The epiphyseal cartilage plate and its surrounding bone from the humeral head were studied histologically at regular intervals. Concomitantly, roentgenographic measurements were performed on the humeri in toto. By the 10th injection significant morphological changes were noted in the cartilaginous plate, followed by complete cessation of bone growth. Severe triglyceride accumulation appeared in the experimental livers and humeral bone marrows. Osteoporosis also occurred and became severe from the 5th wk of triamcinolone administration. Possible explanations for the findings are discussed.