Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ × SJL/J) F 2 mice
- 1 August 2002
- journal article
- Published by Springer Nature in Functional & Integrative Genomics
- Vol. 2 (3) , 120-125
- https://doi.org/10.1007/s10142-002-0067-1
Abstract
The genetic mechanisms that determine muscle size have not been elucidated, even though it is a key musculoskeletal parameter that reflects muscle strength. In this study, we performed a high-density genome-wide scan using 633 (MRL/MPJ × SJL/J) F2 intercross 7-week-old mice to identify quantitative trait loci (QTL) involved in the determination of muscle size. Significant QTL were identified for muscle size and body length. Muscle size (adjusted by body length) QTL were identified on chromosomes 7, 9, 11, 14 (two QTL) and 17, which together explained 19.2% of phenotypic variance in F2 mice, while body length QTL were located on chromosome 2 (two QTL), 9, 11 and 17 which accounted for 28.3% of phenotypic variance in F2 mice. Three significant epistatic interactions between different QTL positions from muscle size and body length were identified (P 2 mice.Keywords
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