THE EFFECT OF DIGOXIN ON THE RIGHT VENTRICULAR PRESSURE IN HYPERTENSIVE AND ISCHAeMIC HEART FAILURE
Open Access
- 1 October 1950
- Vol. 12 (4) , 317-326
- https://doi.org/10.1136/hrt.12.4.317
Abstract
15 cases of left ventricular failure due to hypertensive or ischemic heart disease were studied. 10 cases showed a reduction in right ventricular pressures after digoxin, which was not always accompanied by a measurable increase in cardiac output. These changes were attributed to differential "stimulation" of the failing left ventricle, a fall in pulmonary vascular pressure, and consequent unloading of the right ventricle with resulting fall in venous filling pressure. Digoxin produced a hypertensive response in 8 cases, 3 of which developed a rise in right ventricular pressure and other signs of acute left ventricular failure. 2 patients had an intermediate type of response with a rise in cardiac output without a fall in right ventricular pressure.Keywords
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