The response to ovarian hyperstimulation and in-vitro fertilization in women older than 35 years

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Abstract
There are conflicting reports concerning the effect of female age and potential reproductive function. We assessed the response to ovarian hyperstimulation in two consecutive FVF cycles in 25 women >35 years of age and compared their response to a control group of 48 women 1.0 cm, the number of oocytes recovered and the number of embryos which cleaved did not differ between the older and the younger women. However, conception rates were markedly lower in the older women than the overall pregnancy rate in the FVF programme during the same time period. We conclude that the older women in this study have a normal response to ovarian stimulation but may have a decreased receptivity of the endometrium or increased numbers of embryos with chromosomal abnormalities, leading to a reduced rate of implantation.

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