Efficacies of Zinc-Finger-Active Drugs againstGiardia lamblia
- 1 June 1998
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 42 (6) , 1488-1492
- https://doi.org/10.1128/aac.42.6.1488
Abstract
Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 μM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 μM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.Keywords
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