Studies on the oxidation of amitriptyline

Abstract
The quantitative determination of amitriptyline extracted from biological fluids has been achieved using an oxidation procedure. By use of selective oxidation methods a knowledge of the levels of 10-hydroxylated metabolites of amitriptyline can be obtained. Some evidence is presented that dehydroamitriptyline, or its demethylated derivatives, are natural metabolites of amitriptyline in man.

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