IMMUNOSUPPRESSIVE ACTIVITY OF FUSARIUM TOXINS EFFECTS ON ANTIBODY-SYNTHESIS AND SKIN-GRAFTS OF CRUDE EXTRACTS, T2-TOXIN AND DIACETOXYSCIRPENOL
- 1 January 1979
- journal article
- research article
- Vol. 36 (1) , 111-117
Abstract
The inhibitory effect of crude F. poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody [Ab] to sheep red blood cells [SRBC] and the effect of T2-toxin on skin graft rejection were investigated [in mice]. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol caused a significant reduction in thymus wt and inhibited responsiveness to SRBC. The effect on Ab synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of treatment. The administration of T2-toxin subsequent to immunization stops Ab synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.This publication has 12 references indexed in Scilit:
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