Inhibition of poly(ADP‐ribose) polymerase causes increased DNA strand breaks without decreasing strand rejoining in alkylated HeLa cells
- 14 October 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 190 (2) , 279-282
- https://doi.org/10.1016/0014-5793(85)81300-4
Abstract
Treatment of alkylated HeLa cells with 3-aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, increased the number of DNA strand breaks but did not affect the rate of strand rejoining. This suggests that an increase in DNA incision, not a decrease in ligation, results from the inhibition ofpoly(ADP-ribose) polymerase in cells recovering from DNA damaged by alkylating agents. Poly(ADP-ribose) DNA strand break DNA repairKeywords
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